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When we combined xCT overexpression with GPX4 deletion, we found that elevated Cys availability rescues GPX4-deficient cells from ferroptotic cell death (Fig

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For instance, specialized peptides, like growth hormone secretagogues or mitochondrial-targeting sequences, stimulate Leydig cells in the testes to produce more testosterone via the hypothalamic-pituitary-gonadal axis

Glutathione is a powerful antioxidant produced by the body, composed of three amino acids: glutamine, cysteine, and glycine

Intriguingly, the expression of GPD2 (and also AIFM2, which encodes FSP1) showed a mutually exclusive expression pattern, whereas DHODH showed a positive correlation with LDHB in a large collection of cancer cell lines (Supplementary Fig